Cardarine (GW501516) and GW0742 are two very similar drugs. Cardarine is, however, the most popular of the two. It is commonly used during cutting cycles, where it helps to burn down fats at a rapid rate to reduce overall body fat percentage. It is also used for improving general athletic performance since it is very effective for boosting energy, endurance, and stamina.
GW0742 affects the body in a similar manner as GW501516. Both of them belong to the same class of drugs called PPAR delta agonists. In other words, they improve the activities and performance of the protein called PPAR delta. This means the drugs are technically not selective androgen receptor modulators even though they are widely marketed and sold as such.
Something else both Gw501516 and GW0742 share is their parent company. Both drugs were developed by GlaxoSmithKline. Cardarine was the first to enter the market, and that's why it is also widely used. According to some reports, the PPAR agonist was developed for the sole purpose of extending the patent GlaxoSmithKline has on Cardarine. Other reports suggest that GW0742 was developed to improve the performance of Cardarine. Some users even claim that it’s more potent than GW501516. However, there aren’t any clinical trials showing any significant differences between the two. Therefore, it’s most likely that the impact from both of them is more or less the same.
How Does GW0742 Work?
The clinical research on GW0742 is very limited, so many of the finer details regarding how it affects the body remain unknown. However, since its chemical structure is very similar to Cardarine’s, which is slightly more studied, researchers believe that its effect on the body is also just like Cardarine's. This would mean that the drug improves the gene expression that stimulates fat metabolism, which is what PPAR delta agonists like Cardarine do. And by doing so, the drug effectively boosts fat loss.
This process spikes energy output, and that's why GW0742 users enjoy massive boosts in endurance, stamina, and energy. It's also why these drugs are banned by sports governing bodies like the International Olympic Committee.
Here are some of the benefits of GW0742:
- Rapid Fat Loss
This is by far the most popular benefit of GW0742. The drug increases fat metabolism drastically, allowing your body to shred fat at an insane rate. The results are usually phenomenal, and that's why the drug is so popular in the cutting cycle.
With reduced body fat, the PPAR agonist leaves you with the ripped physique synonymous with advanced bodybuilders.
GW0742 can be used alone, or it can be stacked with other SARMs to intensify the results. For drastic fat loss, the drug is stacked with a SARM like Ostarine.
Take note that SARMs stacks are recommended to experienced bodybuilders only.
- Increased Stamina and Endurance
One reason bodybuilders prefer PPAR agonists like this over typical fat burners is that the drugs do not hang you out to dry as far as energy and performance are concerned. Fat loss supplements can help you burn down fats, but they may leave you feeling weak and lethargic, which would affect your performance in the gym.
GW0742 burns down all the stubborn fat in your body while keeping you fueled enough to sustain your normal training routine. In fact, they will improve your performance as more of the adipose gets metabolized.
The drug also improves the oxidative capacity of muscles hence increasing stamina.
- Improved Lipid Profile
In vivo and in vitro trials show that the PPAR agonist can improve lipid metabolism in the heart leading to a better and healthier lipid profile. This means the drug can prevent cardiovascular diseases, especially in people who are already at risk. Researchers recommend additional clinical studies, though.
- Reduced Total Cholesterol
GW-0742 can reduce total cholesterol levels in the body. Animal studies show it achieves this by reversing cholesterol transportation in the intestines by lowering cholesterol reabsorption. As a result, most of the cholesterol ends up getting excreted from the body. Its impact has actually been compared to the prescription drug Ezetimibe, which is used to treat high blood cholesterol and some lipid abnormalities.
The research on this subject is very limited though
GW0742 is also said to be effective in reducing gut inflammation caused by gut ischemia or reperfusion injury, as reported by this study.
Dosage and Cycle
The lack of thorough research on this drug makes dosing a bit of a challenge. The guideline followed by most people is actually based on Cardarine since we know the two drugs are very similar.
Therefore, the starting dosage for beginners is 10mg per day. Intermediate and advanced users can take higher dosages of up to 25mg per day. Avoid going beyond this point.
GW-0742 should be used in 8-week cycles.
GW0742 Side Effects
There aren't a lot of reported side effects of this drug, probably because it is not widely used. With that said, I believe that Cardarine side effects could also be experienced with this drug.
GW0742 has also been linked to cardiomegaly, a condition characterized by an increase in the size of the heart. According to researchers, this occurs due to the activation of calcineurin. The side effect has so far been observed in animal studies involving rats. It remains to be seen whether the same thing can happen in humans.
The lack of enough clinical studies on this drug limits our ability to tell its short and long-term side effects. It also makes it really hard to know whether cardiomegaly can also happen in humans or not. For most people, this is enough reason to avoid the drug regardless of how beneficial it may be.
Where to buy
We recommend buying GW0742 from Science Bio. Science Bio is a reputable US-based SARMs company that sells pure and potent compounds. They are our favorite SARMs supplier because their quality and consistency remain unmatched.
They have some of the most competitive prices on the market today. A 50ml bottle of 10mg/ml GW-0742 is currently retailing at $59.99. Compared to other vendors, you will spend the same amount of cash for a mere 30ml bottle. That’s a volume difference of almost 70%!
You will also get free shipping if you spend more than $100. International buyers are also eligible for free shipping for orders exceeding $275. Oh, and Science Bio has a same-day shipping policy if you place your orders before the cut-off time.
GW0742 is a very promising drug, but the lack of clinical data hurts its reputation. It’s not just the lack of knowledge on its full benefits and appropriate dosages but also on the potential adverse events. The drug could have long-term side effects that we are totally unaware of. That’s is why most people prefer sticking to Cardarine GW501516, which is better studied and widely used.